Kunio Ishii Selected Research

N-Methylaspartate (NMDA)

4/2021	Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats.
1/2019	Involvement of matrix metalloproteinases in capillary degeneration following NMDA-induced neurotoxicity in the neonatal rat retina.
1/2018	Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina.
1/2018	Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity.
1/2018	[Selective neuronal cell death in retinal degenerative diseases].
10/2017	Opioid receptor activation is involved in neuroprotection induced by TRPV1 channel activation against excitotoxicity in the rat retina.
9/2017	Activation inhibitors of nuclear factor kappa B protect neurons against the NMDA-induced damage in the rat retina.
12/2016	Protective effects of PF-4708671 against N-methyl-d-aspartic acid-induced retinal damage in rats.
11/2016	Apelin-36 is protective against N-methyl-D-aspartic-acid-induced retinal ganglion cell death in the mice.
8/2015	High-mobility group Box-1 is involved in NMDA-induced retinal injury the in rat retina.

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Kunio Ishii Research Topics

Disease

23	Ganglion Cysts (Ganglion) 04/2021 - 08/2009
12	Retinal Diseases 01/2018 - 05/2009
10	Ischemia 01/2018 - 07/2004
10	Glaucoma 01/2018 - 05/2009
8	Cataract (Cataracts) 01/2019 - 01/2008
6	Diabetic Retinopathy (Retinopathy, Diabetic) 03/2021 - 08/2009
6	Retinal Degeneration 01/2019 - 11/2010
5	Hypoxia (Hypoxemia) 01/2018 - 01/2011
4	Diabetes Mellitus 03/2021 - 08/2008
4	Hyperglycemia 01/2019 - 06/2009
4	Reperfusion Injury 08/2015 - 05/2009
4	Fetal Growth Retardation (Intrauterine Growth Retardation) 08/2014 - 01/2010
3	Inflammation (Inflammations) 01/2015 - 08/2009
3	Hyperalgesia 01/2014 - 12/2012
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2018 - 01/2011
2	Retinopathy of Prematurity (Retrolental Fibroplasia) 01/2018 - 02/2016
2	Pre-Eclampsia (Preeclampsia) 03/2014 - 01/2010
2	Wounds and Injuries (Trauma) 10/2013 - 08/2009
2	Neuralgia (Stump Neuralgia) 01/2013 - 12/2012
2	Neoplasms (Cancer) 01/2013 - 12/2012
2	Cystitis 01/2011 - 02/2004
2	Hemorrhage 01/2010 - 04/2003
2	Hypertension (High Blood Pressure) 01/2010 - 06/2007
2	Cardiovascular Diseases (Cardiovascular Disease) 02/2004 - 04/2003
1	Chronic Disease (Chronic Diseases) 01/2018
1	Optic Nerve Diseases (Optic Neuropathy) 01/2018
1	Blindness (Hysterical Blindness) 01/2018
1	Hyperemia 01/2017
1	Brain Injuries (Brain Injury) 01/2017
1	Hyperoxia 10/2015
1	Retinal Artery Occlusion 06/2015
1	Vascular Diseases (Vascular Disease) 05/2015
1	Eye Diseases (Eye Disease) 01/2015
1	Gyrate Atrophy 01/2015
1	Atrophy 01/2015

Drug/Important Bio-Agent (IBA)

28	Retinaldehyde (Retinal)IBA 01/2018 - 07/2004
27	N-Methylaspartate (NMDA)IBA 04/2021 - 05/2009
10	Glutamic Acid (Glutamate)FDA Link 01/2018 - 08/2009
8	Streptozocin (Streptozotocin)FDA Link 01/2019 - 01/2008
8	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 01/2010
5	Pharmaceutical PreparationsIBA 01/2019 - 04/2008
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2017 - 05/2009
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2008
4	Drinking WaterIBA 01/2019 - 01/2008
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 02/2016 - 08/2013
4	Vasodilator Agents (Vasodilators)IBA 02/2015 - 06/2007
4	Acetylcholine (Acetylcholine Chloride)FDA Link 02/2015 - 06/2009
4	N- (2- chloro- 4- ((6,7- dimethoxy- 4- quinazolinyl)oxy)phenyl)- N'- propylureaIBA 08/2014 - 01/2010
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2014 - 12/2012
3	elcatoninIBA 01/2014 - 12/2012
3	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2014 - 12/2012
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2011 - 02/2004
2	ParvalbuminsIBA 04/2021 - 10/2013
2	SugarsIBA 01/2019 - 04/2008
2	Probucol (Lorelco)FDA Link 01/2019 - 12/2017
2	Crystallins (Crystallin)IBA 01/2019 - 01/2018
2	ResveratrolIBA 01/2018 - 09/2011
2	Capsaicin (Zostrix)FDA Link 10/2017 - 06/2014
2	Amlodipine (Norvasc)FDA LinkGeneric 10/2015 - 05/2009
2	Sirolimus (Rapamycin)FDA Link 01/2015 - 01/2014
2	Everolimus FDA Link 01/2015 - 01/2014
2	Tyrosine Kinase InhibitorsIBA 08/2014 - 08/2013
2	Messenger RNA (mRNA)IBA 03/2014 - 04/2003
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2013 - 02/2013
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2013 - 12/2012
2	polyolIBA 01/2012 - 01/2010
2	Aldehyde Reductase (Aldose Reductase)IBA 01/2012 - 01/2008
2	GP 1447IBA 01/2012 - 01/2008
2	BradykininIBA 09/2011 - 01/2011
2	Donepezil (Aricept)FDA LinkGeneric 01/2010 - 01/2010
2	Proteins (Proteins, Gene)FDA Link 03/2006 - 04/2003
2	Nitroarginine (NG Nitro L Arginine)IBA 03/2006 - 04/2003
1	CitrullineIBA 03/2021
1	LipidsIBA 01/2019
1	Hypolipidemic Agents (Antihyperlipidemics)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 01/2018
1	PolyphenolsIBA 01/2018
1	Iron Chelating AgentsIBA 01/2018
1	Morphine (MS Contin)FDA LinkGeneric 10/2017
1	Opioid Receptors (Opioid Receptor)IBA 10/2017
1	Naloxone (Narcan)FDA LinkGeneric 10/2017
1	Narcotic Antagonists (Opioid Antagonists)IBA 10/2017
1	CalcineurinIBA 01/2017
1	Mitogen-Activated Protein KinasesIBA 01/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2017
1	Apelin ReceptorsIBA 11/2016
1	Kainic Acid (Kainate)IBA 11/2016
1	Nicardipine (Dagan)FDA LinkGeneric 10/2015
1	HMGB1 Protein (HMG1)IBA 08/2015
1	Purinergic P2X7 ReceptorsIBA 06/2015
1	Adenosine Triphosphate (ATP)IBA 06/2015
1	AldehydesIBA 05/2015
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 05/2015
1	IronIBA 01/2015
1	Indicators and Reagents (Reagents)IBA 01/2015
1	EnzymesIBA 01/2015

Therapy/Procedure

9	Intravitreal Injections 04/2021 - 01/2013
2	Lenses 01/2012 - 01/2008
1	Chelation Therapy (Therapy, Chelation) 01/2015